Drug Synergism: Synergistic Interaction between Alcohol and other Drugs

Drug synergism is the phenomenon wherein the effects of a medicine is enhanced when taken with different substances. Synergy is defined as the severalise wherein the combined action of constituents is greater than the sum of its parts. The synergistic effect when drugs are taken in junto is due to the fact that each constituent (between two different dugs or between a drug and another substance) contributes to the effect of the other in accordance with its own potency.Chemical reactions between the drug or drugs and other substances, and the chemicals inside the body, particularly in those of the liver, also exist. One substance that can enhance the effects of a drug more than it usually can is alcoholic drink. The combining of alcohol and depressant drug could cause mislead respiratory depressiona disease characterized by fluctuating muscle weakness and fatigabilityperiods of amnesia or loss of memory while intoxicated.The enhanced effect of depressant drug when taken with al cohol could be explained with what happens inside the body. For example, when the depressant drug alprazolam is taken together with alcohol, the liver becomes occupied in metabolizing the alcohol such(prenominal) that the sedative-hypnotic drug is circulated through the body at full strength (Inaba, ). It must be noted that alcohol and certain drugs, especially depressant drugs, compete for the same liver enzymes that break pull down drugs and flush them from the body (Dye, 2007).At the same time, alcohol also dissolves alprazolam more readily than stomach still does, allowing it to be absorbed more rapidly by the body (Inaba, ). As a result, alcohol and alprazolam, or any depressant drugs that can react to alcohol for that matter, can cause more problems when taken in combination than if they were taken at different times. Alcohol, therefore, contributes to the lethality of drug-taking behavior by increasing the effects of drugs taken in tandem with alcohol..Drugs, especially tho se that can cause adverse effects, should be taken with care as the combination of one with another or other substances may enhance its effects. Alcohol, for one, can alter the bodys normal reaction to a specific drug, increasing its effects. It can also react with the drug such that its effects are enhanced. Needless to say, taking alcohol and drugs should be avoided.